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Obesity and reduction of the response rate to anti-tumor necrosis factor α in rheumatoid arthritis: an approach to a personalized medicine

机译：肥胖和类风湿关节炎中抗肿瘤坏死因子α的缓解率降低：一种个性化药物的方法

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摘要

Obesity is a mild, long-lasting inflammatory disease and, as such, could increase the inflammatory burden of rheumatoid arthritis (RA). The study aim was to determine whether obesity represents a risk factor for a poor remission rate in RA patients requiring anti-tumor necrosis factor α (anti-TNFα) therapy for progressive and active disease despite treatment with methotrexate or other disease-modifying antirheumatic drugs.

机译：肥胖是一种轻度，长期的炎症性疾病，因此可能会增加类风湿关节炎（RA）的炎症负担。该研究的目的是确定尽管甲氨蝶呤或其他可改变病情的抗风湿药治疗，但仍需要进行抗肿瘤坏死因子α（anti-TNFα）治疗进行性和活动性疾病的RA患者，肥胖是否代表缓解率低的危险因素。

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作者
Gremese, Elisa; Carletto, Antonio; Padovan, Melissa; Atzeni, Fabiola; Raffeiner, Bernd; Giardina, Anna Rita; Favalli, Ennio Giulio; Erre, Gian Luca; Gorla, Roberto; Galeazzi, Mauro; Foti, Rosario; Cantini, Fabrizio; Salvarani, Carlo; Olivieri, Ignazio; Lapadula, Giovanni; Ferraccioli, Gianfranco;
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1. Obesity and reduction of the response rate to anti-tumor necrosis factor α in rheumatoid arthritis: An approach to a personalized medicine [J] . GremeseE., CarlettoA., PadovanM., Arthritis care & research . 2013,第1期

机译：肥胖和类风湿关节炎中抗肿瘤坏死因子α的缓解率降低：一种个性化药物的方法
2. Obesity and Remission Rates in Japanese Patients With Rheumatoid Arthritis Requiring Anti-Tumor Necrosis Factor Alpha Therapy [J] . Kenji YAMAZAKI, Etsuji SUZUKI2, Ryuhei ISHIHARA, Archives of rheumatology. . 2020,第4期

机译：日本类风湿性关节炎患者肥胖和缓解率，需要抗肿瘤坏死因子α治疗
3. Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort [J] . PlantD., IbrahimI., LuntM., Arthritis research & therapy. . 2012,第5期

机译：英国类风湿关节炎患者中C反应蛋白单倍型与血清C反应蛋白水平及对抗肿瘤坏死因子治疗的反应的相关性：类风湿关节炎遗传学和基因组学研究的生物学结果
4. RHEUMATOID FACTOR-CORRELATED PROTEINS IS COMPLEMENTARY BIOMARKER OF RHEUMATOID ARTHRITIS [C] . Hee-Gyoo Kang, Sora Mun, Arum Park, International Mass Spectrometry Conference . 2018

机译：类风湿因子相关蛋白是类风湿性关节炎的互补生物标志物
5. Predictors of Infection in Rheumatoid Arthritis Patients Using Anti-Tumor Necrosis Factor Agents [D] . Liu, Tasia 2017

机译：类风湿关节炎患者使用抗肿瘤坏死因子药物的感染预测因子
6. Obesity and Remission Rates in Japanese Patients With Rheumatoid Arthritis Requiring Anti-Tumor Necrosis Factor Alpha Therapy [O] . Kenji YAMAZAKI, Etsuji SUZUKI, Ryuhei ISHIHARA, 2020

机译：日本类风湿性关节炎患者肥胖和缓解率需要抗肿瘤坏死因子α治疗
7. Obesity and reduction of the response rate to anti-tumor necrosis factor α in rheumatoid arthritis: an approach to a personalized medicine [O] . Gremese, Elisa, Carletto, A, Padovan, M, 2013

机译：肥胖和类风湿关节炎中抗肿瘤坏死因子α的缓解率降低：一种个性化药物的方法

Obesity and reduction of the response rate to anti-tumor necrosis factor α in rheumatoid arthritis: an approach to a personalized medicine

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